C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/02 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) C07D 207/04 (2006.01)
Patent
CA 2504886
Natural and synthetic compounds having a lactone structure methods for using and making the compounds have been disclosed. The compounds are useful as anti- bacterial, anti-fungal and anti-inflammatory agents, and for treating proliferation disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. The compounds are also effective for treatment or prevention of inflammatory diseases such as artherosclerosis, lung fibrosis, systemic lupus erythematosus, pancreatitis, sarcoidosis, glomerulitis, and organ transplant rejection. They are also effective for treatment or prevention of bacterial and fungal infections, including treatment of peptic ulcers, gastritis, dyspepsia and gastric cancer, gingivitis and periodonditis.
L'invention concerne des composés naturels et synthétiques ayant une structure de lactone ainsi que des procédés d'utilisation et de production des composés. Les composés sont utiles en tant qu'agents antibactériens, antifongiques et anti-inflammatoires, et pour le traitement de troubles à prolifération tels que le mélanome, la leucémie, le cancer du sein, le cancer des poumons, le cancer des ovaires, le cancer du colon, le cancer de l'oesophage, le cancer du foie et le cancer lymphatique. Les composés sont aussi efficaces dans le traitement ou dans la prévention de maladies inflammatoires telles que l'athérosclérose, la fibrose pulmonaire, le lupus érythémateux disséminé, la pancréatite, la sarcoïdose, la glomérulite et le rejet de greffe d'organe. Ils sont aussi efficaces dans le traitement ou dans la prévention d'infections bactériennes et fongiques, y compris le traitement de l'ulcère gastro-diodénal, de la gastrite, de la dyspepsie et du cancer gastrique, de la gingivite et de la parodontite.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Magnachem International Laboratories Inc.
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