Synthetic membrane vesicles containing functionally active...

Details Synthetic membrane vesicles containing functionally active... Synthetic membrane vesicles containing functionally active...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 38/46 (2006.01) A61K 39/12 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2079685

The phospholipid bi-layer vesicle contains at least one pharmaceutically active drug and comprises cell-specific markers on the membrane which have at least 90% biological activity when measured according to Luescher & Glueck, Antiviral Research 14, 39-50. In the membrane, the cholesterol content is preferably less than 2% by weight, the detergent content preferably less than 1 ppb. The vesicle diameter preferably is about 80 nm. The phospholipid in the membrane may comprise 70 to 95% by weight of phosphatidylcholine and preferably 10 to 20% by weight of phosphatidylethanolamine: preferably 6 to 8% by weight of a crosslinker, preferably of a sulfosuccinimidyl derivate, and at least one cell-specific fusion peptide are linked to the membrane. The vesicles are used for the preparation of pharmaceuticals against AIDS and carcinomas.

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