Synthetic membrane vesicles with controlled release of...

Details Synthetic membrane vesicles with controlled release of... Synthetic membrane vesicles with controlled release of...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A01N 25/04 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2176712

A synthetic membrane vesicle composition containing at least one release-rate modifying agent other than a hydrohalide and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number and a controlled release rate of the biologically active substance. A process for making the composition features addition of a release-rate modifying agent effective to prolong, sustain, and control the rate of release from the vesicles of the biologically active substance at therapeutic levels after encapsulation.

Composition pour vésicules à membrane synthétique contenant au moins un agent régulateur du taux de libération autre qu'un hydrohalogénure et au moins une substance biologiquement active. Les vésicules présentent une distribution en taille définie, une taille moyenne ajustable, une taille de chambre et un nombre de chambres ajustables et un taux de libération de la substance biologiquement active contrôlable. Procédé pour rendre efficaces les caractéristiques de la composition, après adjonction d'un agent régulateur du taux de libération, en vue de ralentir, maintenir, et contrôler le taux de libération de la substance biologiquement active contenue dans les vésicules pour lui assurer un niveau thérapeutique après encapsulation.

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