Synthetic nano-sized crystalline calcium phosphate and...

C - Chemistry – Metallurgy – 01 – B

Patent

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C01B 25/32 (2006.01)

Patent

CA 2569756

Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described. The method comprises formation of a liquid crystalline phase in a water solution of calcium, phosphor and a surfactant, placing the phase in an ammonia atmosphere so that nano-sized crystals are formed, followed by either removal of the surfactant with a solvent and recovering the nano-sized crystals to obtain the powder, or diluting the ammonia-treated liquid crystalline phase with a hydrophobic organic solvent to create a microemulsion of the nano-sized crystals in water, dipping an oxide layer-coated surface of an object into the microemulsion, or alternatively saving the step of ammonia treatment of the liquid crystalline phase until after the dipping of the surface of an object into the microemulsion, followed by removal of the organic solvent and the surfactant from the surface to obtain the coating.

Un phosphate de calcium cristallin nanométrique et synthétique, particulièrement un hydroxyapatite, ayant une zone de surface spécifique allant de 150 m?2¿/g à 300 m?2¿/g. Le phosphate de calcium cristallin nanométrique peut être sous forme de poudre ou d'un revêtement sur une surface. Un procédé de production de la poudre de phosphate de calcium cristallin nanométrique ou son revêtement. Le procédé consiste à former une phase cristalline liquide dans une solution d'eau de calcium, de phosphore et un tensio-actif, placer la phase dans un milieu à l'ammoniac de manière à former des cristaux nanométriques, puis soit retirer le tensio-actif avec un solvant et recouvrir les cristaux nanométriques afin d'obtenir la poudre, soit diluer la phase cristalline liquide traitée par ammoniac avec un solvant organique hydrophobe afin de créer une micro-émulsion des cristaux liquides nanométriques dans l'eau, immerger la surface revêtue d'une couche d'oxyde d'un objet dans la micro-émulsion, ou conserver l'étape de traitement par ammoniac de la face cristalline liquide jusqu'à la fin de l'immersion de la surface d'un objet dans la micro-émulsion, finalement retirer le solvant organique et le tensio-actif de la surface afin d'obtenir le revêtement.

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