Synthetic oligomers having chirally pure phosphonate...

Details Synthetic oligomers having chirally pure phosphonate... Synthetic oligomers having chirally pure phosphonate...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2176256

Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.

Oligomères ayant des liaisons internucléosidyle phosphonate chiralement pures mélangées avec des liaisons internucléosidyle non phosphonate qui s'hybrident à des séquences cibles d'ARN et procédés de préparation desdits oligomères.

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