Synthetic pathway enzymes for the production of argyrins

Details Synthetic pathway enzymes for the production of argyrins Synthetic pathway enzymes for the production of argyrins

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01) C12N 15/52 (2006.01) C12P 17/16 (2006.01)

Patent

CA 2726297

The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences encoding the synthetic pathway enzymes participating in the production of Argyrins, as well as genetically manipulated micro- organisms containing nucleic acid sequences encoding the synthetic pathway enzymes for the production of Argyrins, e.g. for inserting one or more of these coding sequences, mutating in a targeted manner one or more of these nucleic acid sequences, in a wild type producer micro-organism or in a heterologous micro-organism, for the production of Argyrins.

L'invention concerne des séquences d'acides aminés comprises dans, ou constituant, des enzymes de voies de synthèse participant à la production d'argyrines, ainsi que les séquences d'acide nucléique codant les enzymes de voies de synthèse participant à la production d'argyrines, ainsi que des micro-organismes génétiquement manipulés contenant des séquences d'acide nucléique codant les enzymes de voies de synthèse pour la production d'argyrines, par exemple par l'insertion d'une ou plusieurs de ces séquences codantes, la mutation ciblée d'une ou plusieurs de ces séquences d'acide nucléique, dans un micro-organisme producteur sauvage ou dans un micro-organisme hétérologue, pour la production d'argyrines.

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