Synthetic peptide derived from human lipocortin v and use...

Details Synthetic peptide derived from human lipocortin v and use... Synthetic peptide derived from human lipocortin v and use...

C - Chemistry, Metallurgy

07

K

167/103.05, 530/

C07K 7/06 (2006.01) A61K 38/08 (2006.01)

Patent

CA 2034618

SYNTHETIC PEPTIDE DERIVED FROM HUMAN LIPOCORTIN V AND USE THEREOF ABSTRACT OF THE DISCLOSURE The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val- Phe-Asp-Lys-OH and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. Said peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.

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