Synthetic peptide inhibitors of hiv transmission

Details Synthetic peptide inhibitors of hiv transmission Synthetic peptide inhibitors of hiv transmission

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 38/00 (2006.01) A61K 39/155 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/09 (2006.01) C07K 5/093 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 5/113 (2006.01) C07K 5/117 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/005 (2006.01) C07K 14/02 (2006.01) C07K 14/05 (2006.01) C07K 14/11 (2006.01) C07K 14/115 (2006.01) C07K 14/12 (2006.01) C07K 14/125 (2006.01) C07K 14/13

Patent

CA 2164698

The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LaI gp41 protein, and fragments analogs and hamologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.

L'invention porte sur des peptides présentant une puissante activité antivirale. Lesdits peptides sont des DP-178 (SEQ ID:1) correspondant aux acides aminés 638 à 673 de la protéine du VIH-1LAI gp41, ainsi que des fragments, des analogues et des homologues des DP-178. L'invention porte également sur l'utilisation desdits peptides comme inhibiteurs de la transmission de rétrovirus, et particulièrement du VIH, à des cellules non infectées, chez l'homme et chez l'animal.

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