Synthetic peptide of regulatory virus protein r (vpr) of...

Details Synthetic peptide of regulatory virus protein r (vpr) of... Synthetic peptide of regulatory virus protein r (vpr) of...

C - Chemistry, Metallurgy

07

K

C07K 14/155 (2006.01) A61K 39/21 (2006.01) A61K 47/48 (2006.01) C07K 1/16 (2006.01) C07K 14/16 (2006.01) C12N 15/87 (2006.01) C12P 21/00 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2356390

The invention pertain to synthetic (s) peptides derived from the viral regulatory protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly the chemical synthesis of the 96 amino acid full length Vpr protein (sVpr1-96), of a 47 amino acid long N- terminal (sVpr1-47), of a 49 amino acid long C-terminal fragment (sVpr48-96) as well as fragments thereof (sVpr1-20 and sVpr21-40) and further approximately 15 amino acid long fragments of sVpr1-96. As fragments or full length products of the HIV-1 regulatory protein those products are used in biological assays, for molecular and structural characterization of Vpr and domains thereof , as well as for the development of anti-Vpr antibodies directed against Vpr peptide sequences.

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