Synthetic peptide vaccine for chlamydia trachomatis

Details Synthetic peptide vaccine for chlamydia trachomatis Synthetic peptide vaccine for chlamydia trachomatis

C - Chemistry, Metallurgy

07

K

C07K 14/295 (2006.01) A61K 39/118 (2006.01) G01N 33/571 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2144882

A synthetic peptide capable of producing an immunological response to C. trachomatis in a vertebrate is disclosed. The synthetic peptide comprises at least one conserved T-helper cell stimulating epitope located within the peptide sequence AL- NIWDRFDVFCTLGATTGYLKGNS and at least one B-cell neutralizing antibody stimulating epitope located within the pep- tide sequence FDVTTLNPTIAGAGDVK. In a preferred embodiment, the epitopes are colinear and in a particularly preferred embodiment the T-helper cell stimulating epitope is located closer to the N-terminus of the peptide than the B-cell neutralizing antibody stimulating epitope.

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