C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/139, 167/37,
C07K 7/08 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 14/16 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1305828
ABSTRACT OF THE DISCLOSURE Composition and method for detection of and vaccination against the viral causative agents of AIDS and ARC. The composi- tion is a synthetic peptide, the amino acid sequence of which is sufficiently homologous to the amino acid sequence of the gp 41 and gp 120 subunits of the gp 160 envelope glycoprotein of HTLV- III, LAV or ARC to produce an immunogenic response in a patient and which has a hydrophilic region therein. The composition may be conjugated to an appropriate carrier for use as a vaccine against AIDS and ARC or bound to the ligand of a specific binding pair, contacted with a sample of biological fluid from a patient suspected of having contracted AIDS or ARC and thereafter con- tacted with the anti-ligand of the specific binding pair for de- tection of any antibodies against the viral causative agents of AIDS or ARC which may be present in the sample. 01/MRWDEB
521246
Dreesman Gordon R.
Essex Myron E.
Kennedy Ronald C.
Dreesman Gordon R.
Essex Myron E.
Kanda Patrick
Kennedy Ronald C.
Osler Hoskin & Harcourt Llp
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