Synthetic peptides and uses therefore

Details Synthetic peptides and uses therefore Synthetic peptides and uses therefore

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) C07K 2/00 (2006.01) C07K 14/005 (2006.01) C07K 14/15 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C07K 14/20 (2006.01) C07K 14/435 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2408125

A synthetic polypeptide is disclosed, which comprises a plurality of different segments of at least one parent polypeptide, wherein the segments are linked together in a different relationship relative to their linkage in the at least one parent polypeptide to impede, abrogate or otherwise alter at least one function associated with the parent polypeptide. Synthetic polynucleotides are also disclosed that code for the synthetic polypeptides of the invention as well as expression constructs comprising the synthetic polynucleotides. Also disclosed are methods for constructing the aforementioned molecules and immunopotentiating compositions and methods for treating and/or preventing a disease or condition.

La présente invention concerne un polypeptide synthétique qui comprend une pluralité de segments différents issus d'au moins d'un polypeptide parent, ces segments étant reliés ensemble selon une relation différente par rapport à leur schéma de liaison dans le polypeptide parent pour empêcher, supprimer ou encore modifier au moins une fonction associée au polypeptide parent. Par ailleurs, cette invention concerne des polynucléotides synthétiques qui codent les polypeptides synthétiques de l'invention ainsi que des produits de synthèse d'expression qui comprennent lesdits polynucléotides synthétiques. Cette invention concerne également des méthodes d'élaboration des molécules précitées, des compositions de potentialisation immunologique, ainsi que des méthodes de traitement et/ou de prévention d'une maladie ou d'un état pathologique.

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