Synthetic peptides containing citrulline recognized by...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) A61K 38/17 (2006.01) C07K 1/107 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2309534

The present invention relates to a method of producing certain peptides containing citrulline residues that constitute immunogenic determinants of antibodies present in sera from patients with rheumatoid arthritis and wherein the presence of at least one citrulline is a prerequisite for reacting with said antibodies. The invention also relates to a method of producing said antibodies and the use of said peptides for diagnosis and treatment of rheumatoid arthritis.

L'invention porte sur un procédé de production de certains peptides contenant des résidus de citrulline qui constituent des déterminants immunogènes d'anticorps présents dans les sérums de patients atteints de polyarthrite rhumatoïde, et dans lesquels la présence d'au moins une citrulline est une condition préalable à la réaction avec lesdit anticorps. L'invention porte également sur un procédé de production desdits anticorps et sur l'utilisation desdits peptides pour le diagnostic et le traitement de la polyarthrite rhumatoïde.

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