C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/16 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) A61P 31/18 (2006.01) C07K 7/00 (2006.01)
Patent
CA 2732215
The present invention relates to chimeric peptides having a caveolin-1 binding domain of an HIV-1 gp41 (CBD1) peptide or a variant of said CBD1, fused to a T helper epitope. In one aspect, the T epitope is from a peptide selected from the group consisting of a tetanus toxin, an HIV-1 Gag p24 and an HIV-1 Env-gp120. Compositions containing these chimeric peptides and pharmaceutical and immunogenic compositions as well as vaccines comprising these chimeric peptides also are part of the present invention. Methods to induce neutralizing antibodies against HIV-1 activity and uses of the chimeric peptides to treat or to prevent HIV-1 infection are also disclosed.
La présente invention concerne des peptides chimères ayant une domaine de liaison de cavéoline 1 dun peptide gp41 (CBD1) de VIH-1 ou un variant dudit CBD1, fusionné avec un épitope de lymphocyte T auxiliaire. Dans un aspect, lépitope T est dun peptide choisi dans le groupe constitué dune toxine tétanique, Gag p24 de VIH-1 et Env-gp120 de VIH-1. La présente invention concerne en outre des compositions contenant des peptides chimères et des compositions pharmaceutiques et immunogènes ainsi que des vaccins comprenant ces peptides chimères. La présente invention concerne en outre des procédés pour induire des anticorps neutralisants contre lactivité VIH-1 et des utilisations des peptides chimères pour traiter ou prévenir linfection par VIH-1.
Hovanessian Ara
Krust Bernard
Centre National de La Recherche Scientifique
Goudreau Gage Dubuc
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