Synthetic peptides for the treatment of myasthenia gravis

Details Synthetic peptides for the treatment of myasthenia gravis Synthetic peptides for the treatment of myasthenia gravis

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2138258

Peptides having at least nine amino acid residues each including an amino acid sequence which corresponds to position p200-208 or p262-266 of the human acetylcholine receptor .alpha.-subunit, but differing therefrom by one or more amino acid substitu- tions, are disclosed. These peptides inhibit the proliferative response of human peripheral blood lymphocytes to the myasthogenic peptides p195-212 and p259-271 and are suitable for treatment of subjects afflicted with myasthenia gravis.

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