C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/11 (2006.01) A61K 8/64 (2006.01) A61P 17/02 (2006.01) A61Q 19/00 (2006.01) C07K 7/06 (2006.01) C07K 14/78 (2006.01)
Patent
CA 2647775
The present invention relates to peptides of general formula (I) that are capable of regulating fibrillogenesis, stereoisomers thereof and mixtures thereof, which may or may not be racemic, and the cosmetically or dermopharmaceutically acceptable salts thereof, in which Z is alanyl, allo-isoleucyl, glycyl, isoleucyl, isoseryl, isovalyl, leucyl, norleucyl, norvalyl, prolyl, seryl, threonyl, allo-threonyl or valyl; n and m may vary between 1 and 5; AA is selected from the group formed by natural amino acids encoded in their L- or D- form and non-encoded amino acids; x and y may vary between 0 and 2; R1 is H or an alkyl, aryl, aralkyl or acyl group; and R2 is amino, hydroxyl or thiol, all these possibly being substituted with aliphatic or cyclic groups. A method for obtaining cosmetic or dermopharmaceutical compositions containing them and use thereof for treating the skin, preferably those skin conditions that require the regulation of fibrillogenesis, such as aging and/or the softening of the appearance of scars.
La présente invention se rapporte à des peptides de formule générale (I) aptes à réguler la fibrillogenèse, à leurs stéréo-isomères et leurs mélanges racémiques ou non, ainsi qu'à leurs sels cosmétiquement ou dermopharmaceutiquement acceptables, où Z est alanyle, allo-isoleucyle, glycyle, isoleucyle, isoséryle, isovalyle, leucyle, norleucyle, norvalyle, prolyle, séryle, thréonyle, allo-thréonyle ou valyle; n et m peuvent varier entre 1 et 5; AA est sélectionné dans le groupe constitué d'acides aminés naturels codifiés sous leur forme L- ou D- et acides aminés non codifiés; X et Y peuvent varier entre 0 et 1; R1 est H o groupe alkyle, aryle, aralkyle ou acyle; et R2 est amine, hydroxyle ou thiol, tous étant substitués ou non avec des groupes aliphatiques ou cycliques. L'invention se rapporte également à un procédé d'obtention, à des compositions cosmétiques ou thermopharmaceutiques les contenant et à leur utilisation dans le traitement cutané, de préférence des maladies cutanées nécessitant la régulation de la fibrillogenèse, notamment le vieillissement et/ou l'atténuation des cicatrices.
Alminana Domenech Nuria
Carreno Serraima Cristina
Cebrian Puche Joan
Passerini Elena
Puig Montiel Arturo
Lipotec S.a.
Sim & Mcburney
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