Synthetic phosphodiester oligonucleotides and therapeutical...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2712705

A composition of phosphodiester oligonucleotides of various defined sizes has been created that mimics the effects of defibrotide. The composition essentially consists of mixtures of synthetic phosphodiester oligonucleotides comprising Nmers ranging from 40 mers to 65 mers. The phosphodiester oligonucleotides are preferably heteropolymers composed of either A, G, C, and T at each position but may also be homopolymers, i.e. the same base may be present at each position in the oligonucleotide. These mixtures are effective in the treatment of cancer and other diseases.

La présente invention concerne une composition artificielle d'oligonucléotides, qui présentent une fonction phosphodiester, qui peuvent avoir différentes dimensions définies, et qui imitent les effets du défibrotide. Cette composition est essentiellement constituée de mélanges d'oligonucléotides synthétiques à fonction phosphodiester comprenant des N-mères allant des 40-mères aux 65-mères. Ces oligonucléotides à fonction phosphodiester, qui sont de préférence des hétéropolymères comprenant chacun des A, G, C et T à chaque position, peuvent également être des homopolymères, c'est-à-dire que la même base peut être présente à chaque position de l'oligonucléotide. Ces mélanges conviennent au traitement de cancer et d'autres pathologies.

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