Synthetic platelets

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 35/14 (2006.01) A61K 47/24 (2006.01) A61K 47/28 (2006.01) A61K 47/34 (2006.01) A61K 47/42 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2599849

A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross- linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.

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