Synthetic polymeric drugs

Details Synthetic polymeric drugs Synthetic polymeric drugs

A - Human Necessities

61

K

167/139, 167/166

A61K 47/48 (2006.01)

Patent

CA 1305053

ABSTRACT SYNTHETIC POLYMERIC DRUGS A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety- and an optional cross-linkage, comprises: (a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl)methacrylamide, (b) 0.2 to 20.0 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a bioactive moiety, (c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-methacryloylated aminoacid or peptide, to which are bound a determinant capable of interacting with spedific receptors on cell surfaces, (d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly attached to a similar peptide group attached to another polymer chain, and (e) optionally, as a bioassay label, 0 to 2 mol % of units derived fron N-methacryloylated tyrosinamide.

498931

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