C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 167/139
C07K 7/00 (2006.01) C07K 14/05 (2006.01) C07K 17/02 (2006.01) G01N 33/531 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1292839
ABSTRACT Antigens, immunogens, inocula, antibodies, diagnostic methods and systems relating to Epstein-Barr virus nuclear antigen (EsNA) are disclosed. Each of the compounds, compositions, methods or systems contains a synthetic, random copolymer polypeptide having about 6 to about 40 residues, or an antibody containing site that immunoreacts with such a polypeptide. The polypeptide includes the five amino acid residue sequence Image , wherein R1 and R2 are the same or different amino acid residues selected from the group consisting of Ala, Asn, Arg, Gly, Leu, Pro, Ser, and Thr, with the provision that Rl and R2 are not both Gly. The polypeptide contains at least 25 mole percent Gly residues, and when linked to a carrrier and introduced in an effective amount into a mammalian host is capable of inducing production of antibodles that immunoreact with EBNA.
488208
Carson Dennis A.
Houghten Richard
Rhodes Gary
Vaughan John H.
Fetherstonhaugh & Co.
Scripps Clinic And Research Foundation
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