Synthetic polypeptides as inhibitors of hiv-1

Details Synthetic polypeptides as inhibitors of hiv-1 Synthetic polypeptides as inhibitors of hiv-1

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2092519

Synthetic HIV-1-based polypeptides as well as methods for treating HIV-1 infections are provided herein. The polypeptides of the present invention have amino acid sequences substantially corresponding to a specified region of the HIV-1IIIB virus. The polypeptides of the present invention may be administered in effective amounts for preventing and treating HIV-1 infections. The polypeptides are useful for inhibiting the replication of the HIV-1 virus as well as HIV-1-mediated cytopathogenesis and cell fusion at levels which are within acceptable ranges of cytotoxicity.

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