C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/16 (2006.01) C07K 16/42 (2006.01) C07K 17/00 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2118033
2118033 9321218 PCTABScor01 A synthetic polypeptide has at least one antigenic property of the envelope protein of at least one strain of Human Immunodeficiency Virus (HIV), said polypeptide consists substantially of an amino acid sequence of the formula (I): X-R1-Leu-R2-Leu-Thr-Val-Trp-Gly-R3-Lys-Y, wherein R1 is selected from Gln-Gln-R4-R5, Gln-R4-R5, R4-R5, R5 or R1 is absent; R2 is an amino acid residue selected from Gln, Lys, Glu or Arg; R3 is an amino acid residue selected from Ile, Thr or Ala; R4 is His or Glu; R5 is Leu or Met; and X and Y may each independently be absent or independently be one or more amino acid residues. Preferred peptides are (Ia): X-Gln-Gln-His-Leu-Leu-Gln-Leu-Thr-Val-Trp-Gly-Ile-Lys-Y; (Ib): X-Leu-Gln-Leu-Thr-Val-Trp-Gly-Ile-Lys-Y; (IIa) X-Gln-Gln-Glu-Met-Leu-Arg-Leu-Thr-Val-Trp-Gly-Thr-Lys-Y; and (IIb): X-Leu-Arg-Leu-Thr-Val-Trp-Gly-Thr-Lys-Y and desirably X is absent and Y is Gly-Cys or Gly-Cys-Ala. The peptides are similar to certain epitopes of HIV envelope proteins.
Aston Roger
Fishleigh Robert V.
Robson Barry
Fetherstonhaugh & Co.
Proteus Molecular Design Limited
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