A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/20 (2006.01)
Patent
CA 2203791
The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity, or anti-inflammatory activity. The polyunsaturated fatty acids contain a 16-26 carbon chain, 3-6 double bands and are covalently coupled at the carboxylic acid group to an amino acid. It is preferred that the fatty acid contains 18-22 carbons and that the amino acid is glycine or aspartic acid. Preferred compounds are .gamma.-linolenic acid-glycine, .alpha.-linolenic acid-glycine, arachidonic acid-glycine, docosahexaenoic acid-glycine, eicosapentaenoic glycine, .gamma.- linolenic acid - aspartic acid, .alpha.-linolenic acid - aspartic acid, arachidonic acid - aspartic acid, eicosapentaenoic acid - aspartic acid and docosahexaenoic acid - aspartic acid.
La présente invention concerne des composés d'acides gras polyinsaturés présentant une activité antipaludéenne et/ou neutrophilo-stimulante, ou une activité anti-inflammatoire. Ces acides gras polyinsaturés, qui contiennent une chaîne de 16 à 26 atomes de carbones et 3 à 6 bandes doubles, sont couplés en covalence au groupe carboxylique d'un acide aminé. Dans une réalisation préférée, l'acide gras contient de 18 à 22 atomes de carbones et l'acide aminé est l'acide aminoacétique ou l'acide aspartique. Les composés préférés sont acide .gamma.-linoléïque - acide aminoacétique, acide .alpha.-linoléïque - acide aminoacétique, acide arachidonique - acide aminoacétique, acide docosahexaénoïque - acide aminoacétique, acide eicosapentaénoïque - acide aminoacétique, acide .gamma.-linoléïque - acide aspartique, acide .alpha.-linoléïque - acide aspartique, acide arachidonique - acide aspartique, acide eicosapentaénoïque - acide aspartique et acide docosahexaénoïque - acide aspartique.
Ferrante Antonio
Poulos Alfred
Rathjen Deborah Ann
Schober Paul Adam
Sleigh Merilyn Joy
Children Youth And Women's Health Service Incorporated
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Peptide Technology Limited
Women's And Children's Hospital Adelaide
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