Synthetic polyvalent carbohydrates as components of...

Details Synthetic polyvalent carbohydrates as components of... Synthetic polyvalent carbohydrates as components of...

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 31/715 (2006.01) A61K 31/785 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) C08F 8/00 (2006.01) C08F 20/54 (2006.01) G01N 33/53 (2006.01) C07H 3/00 (2006.01) C07H 15/02 (2006.01)

Patent

CA 2663633

Inhibitors that block the DC-SIGN mediated transmission of the HIV-I virus from mucosal infection sites to T-lymphocytes. In one embodiment, the inhibitors include at least one oligosaccharide chain attached to a scaffolding framework in which the number of the oligosaccharide chains attached to the scaffold can be 2, 3, 4 or more. In another embodiment, HIV-I viral infection is treated by administration of a composition including a therapeutically effective amount of an oligosaccharide cluster and/or oligosaccharide/protein cluster binding DC-SIGN, to inhibit DC-SIGN from binding to HIV envelope glycoprotein.

L'invention concerne des inhibiteurs qui bloquent la transmission à médiation DC-SIGN du virus VIH-I, des sites d'infection de muqueuses vers les lymphocytes T. Dans une forme de réalisation, les inhibiteurs comprennent au moins une chaîne d'oligosaccharides fixée à une structure d'échafaudage, le nombre de chaînes d'oligosaccharides fixées à l'échafaudage étant égal ou supérieur à 2, 3 ou 4. Dans un autre mode de réalisation, l'infection virale à VIH-I est traitée par l'administration d'une composition comprenant une quantité théapeutiquement efficace d'un groupement d'oligosaccharides et/ou d'un groupement d'oligosaccharides/protéine se liant à DC-SIGN, qui inhibe la liaison entre DC-SIGN et la glycoprotéine d'enveloppe du VIH.

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