Synthetic process for the manufacture of an ecteinaschidin...

Details Synthetic process for the manufacture of an ecteinaschidin... Synthetic process for the manufacture of an ecteinaschidin...

C - Chemistry, Metallurgy

07

D

C07D 515/22 (2006.01) A61K 35/00 (2006.01) C07D 221/00 (2006.01) C07D 241/00 (2006.01) C07D 291/00 (2006.01) C07D 317/00 (2006.01) C07D 471/18 (2006.01) C07D 491/22 (2006.01)

Patent

CA 2406095

Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxy, di-6,8-en-5-one fused ring compound. After formation of the 1,4 bridge, C-18 protection is removed before spiroamine introduction.

L'invention concerne des procédés destinés à préparer des composés présentant une structure de cycles accolés de formule (XIV). De tels composés peuvent être des ectéinascidines et comportent un pont spiroamine-1,4. Ledit procédé consiste à former un pont 1,4 au moyen d'un composé l-labile à cycles accolés de 10-hydroxy, di-6,8-ène-5-one avec protection hydroxy en position 18. Après formation du pont 1,4, la protection C-18 est retirée avant introduction de spiroamine.

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