Synthetic proteins as implantables

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/00 (2006.01) A61L 17/00 (2006.01) A61L 17/10 (2006.01) A61L 27/00 (2006.01) A61L 27/22 (2006.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01) C07K 14/78 (2006.01) C08J 5/18 (2006.01) C12N 15/11 (2006.01) D01F 4/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2183644

Copolymers are provided having varying ratios of elastin and fibroin repeating units. By varying the length of segments of the elastin and fibroin repeating units, the absorption can be greatly varied. Tensile strengths remain relatively constant regardless of the composition within the prescribed ranges. The copolymer compositions and recombinant fibroin can be used for the production of a wide variety of formed objects and amorphous masses for use as implants.

La présente invention concerne des copolymères caractérisés par des proportions variables d'unités récurrentes d'élastine et de fibroïne. Il est possible de faire varier fortement le coefficient d'absorption en modifiant la longueur des segments des unités récurrentes d'élastine et de fibroïne. La résistance à la traction reste relativement constante quelle que soit la composition, mais à condition qu'elle reste dans les limites de formulation spécifiées. Les compositions de copolymères et la fibroïne recombinante sont utilisables pour la production d'une grande variété d'objets formés et de masses amorphes utilisables en implants.

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