C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/21 (2006.01) A61K 38/10 (2006.01) A61K 39/104 (2006.01) A61P 31/04 (2006.01) C07K 7/08 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2443232
Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P. aeruginosa pilin protein. The pure polypeptide com- prises at least one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant site of P, aeruginosa pilin. The amino acid residue sequence can repeat as a unit one or more times in the same polypeptide molecule. More than one of such re- peating units and more than one repeating unit of the same type can be present in a single polypeptide molecule. The polypep- tides act as antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. aeruginosa infection.
Doig Peter C.
Hodges Robert S.
Irvin Randall T.
Lee Kok K.
Parami Sastry A.
Sim & Mcburney
The Governors Of The University Of Alberta
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