Synthetic repetitive proteins, their production and use thereof

Details Synthetic repetitive proteins, their production and use thereof Synthetic repetitive proteins, their production and use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 8/64 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2690658

A repetitive protein having repetition units comprising the consensus sequence (I) X1 X2 X3X4 S X5 X6 Y G derived from resilin, wherein X1 is G, Y, A or N; X2 is G, L, Q; X3 is R, K, T or P; X4 is P, A, T or S; X5 is D, T or S; X6 is S, Q or T, and the consensus sequence (II) Z1 Z2 (Z3A)n Z4 Z5 Z6 derived from spider silk, wherein Z1 is S, Q, N, T or G; Z2 is not an amino acid or A; Z3 is A or G; Z4 is not an amino acid, A or S; Z5 is G, S, Q; N or T; Z6 is G, P, S, Q, N or T; and n is a natural whole number wherein 2<=n<=12.

L'invention concerne une protéine répétitive avec des unités répétitives, qui est la séquence de consensus issue de la résiline (I) X1 X2 X3X4 S X5 X6 Y G, et X1 G, Y, A ou N; X2 G, L, Q; X3 R, K, T ou P; X4 P, A, T ou S; X5 D, T ou S; X6 S, Q ou T, et la séquence de consensus issue de soie d'araignée (II) Zi Z2 (Z3A)nZ4 Z5 Z6 et Z1 S, Q, N, T ou G; Z2 aucun acide aminé ou A; Z3 A ou G; Z4 aucun acide aminé, A ou S; Z5 G, S, Q; N ou T; Z6 G, P, S, Q. N ou T; n est un entier naturel avec 2 = n = 12.

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