Synthetic resin

Details Synthetic resin Synthetic resin

C - Chemistry, Metallurgy

08

F

402/453, 402/573

C08F 8/00 (2006.01) C07K 1/04 (2006.01) C08F 8/30 (2006.01) C12N 1/08 (2006.01)

Patent

CA 1318462

4-16403/+ Synthetic resin Abstract A synthetic resin based on a polystyrene that cna be used as a support for soild phase peptide synthesis and that has been cross-linked with from 0 to 5 mol% of divinyl benzene, characterised in that it has been substituted at benzene rings of its skeletal structure by groups of the formula Image (I) in which X represents -O- or -NH- and R represents C1-C4-alkyl, as a support renders possible the solid phase synthesis of peptides and peptide amides that are, if desired, protected at the N-terminal and/or at other functional groups. The resin is manufactured by reaction of a customary chloromethylated polystyrene resin with an alkali metal salt of the corresponding 4-hydroxybenzophenone and subsequent reduction of the carbonyl group and, optionally, amination. .

562701

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