Synthetic rna-based agonists of tlr7

Details Synthetic rna-based agonists of tlr7 Synthetic rna-based agonists of tlr7

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 39/39 (2006.01) A61K 31/7115 (2006.01) A61K 31/7125 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2752694

The invention relates to the therapeutic use of nov-el stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention pro-vides novel RNA-based oligoribonucleotides with improved nu-clease and RNase stability and that selectively induce immune modulatory activity through TLR7.

La présente invention concerne l'utilisation thérapeutique de nouveaux oligoribonucléotides stabilisés en tant qu'agents immunomodulateurs pour des applications d'immunothérapie. L'invention concerne spécifiquement de nouveaux oligoribonucléotides à base d'ARN ayant une plus grande stabilité de nucléase et de RNase et qui induisent sélectivement une activité immunomodulatrice par le biais de TLR7.

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