Synthetic salicylihalamides, apicularens and derivatives...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 313/00 (2006.01) A61K 31/357 (2006.01) A61P 35/00 (2006.01) C07D 493/08 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2417994

The present invention provides compounds having improved stability over that of natural benzolactones, and a process for synthesizing these compounds. These compounds exhibit anti-cancer activity and inhibit V-ATPase activity.

La présente invention concerne, d'une part des composés présentant une meilleure stabilité que celle des benzolactones neturels, et d'autre part un procédé de synthèse de ces composés. Ces composés, qui font preuve d'une activité anticancéreuse, inhibent l'activité V-ATPase.

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