Synthetic saposin c-derived neurotrophic peptides

Details Synthetic saposin c-derived neurotrophic peptides Synthetic saposin c-derived neurotrophic peptides

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2284105

Non-naturally occurring synthetic peptide analogs derived from the active neurotrophic region of saposing C. The saposin C-derived peptides induce neurite outgrowth in vitro, promote myelination, promote neuroprotection and prevent programmed cell death and have an analgesic effect. They are useful in the treatment of central and peripheral nervous system disorders and pain management.

L'invention concerne des analogues de peptides de synthèse non naturels dérivés de la région neurotrophique active de la saposine C. Les peptides dérivés de la saposine C induisent des excroissances des axones, favorisent la myélinisation et la neuroprotection, empêchent la mort cellulaire programmée et possèdent un pouvoir analgésique. Ils sont utiles dans le traitement des troubles du système nerveux périphérique et central et dans le traitement de la douleur.

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