C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/129, 530/17.
C07K 5/10 (2006.01) C07K 5/113 (2006.01) C07K 7/04 (2006.01) C07K 14/245 (2006.01) C07K 16/12 (2006.01) C07K 17/02 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1246054
A B S T R A C T The invention relates to novel synthetic peptides, process for their preparation and their application to the production of antibodies. These peptides include at the most 18 amino-acids and at the least 4 amino-acids in which n is equal to 1 or 2, and when n equals 1 the peptidic sequence P is contained in the following peptidic chain: Asn-Thr-Phe-Tyr-Cys-Cys-Glu-Leu-Cys-Cys-A-Pro-Ala-Cys- Ala-Gly-Cys-T in which either A represents Asn and T represents Tyr, or A represents Tyr and T represents Asn and in which the thiol groups of the possible cysteyl residues are protected by groups stable under biological con- ditions. Use for the production of antibodies capable of replacing biological activity particularly of enterotoxins produced by Escherichia coli strains.
426666
Boquet Patrice
Duflot Anabela
Duflot Edith
Gras Helene
Tartar Andre
Goudreau Gage Dubuc
Institut Pasteur
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