System and method for analyte measurement using a nonlinear...

G - Physics – 01 – N

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G01N 33/487 (2006.01) C12Q 1/00 (2006.01) G01N 27/02 (2006.01) G01N 27/49 (2006.01)

Patent

CA 2686185

The systems and methods of the present invention utilize a linear component of a non-linear, Faradaic current response generated by a biological fluid sample when an AC excitation potential sufficient to produce such a Faradaic current response is applied to the sample, in order to calculate the concentration of a medically significant component in the biological fluid sample. The current response is created by the excitation of electrochemical processes within the sample by the applied potential. Typically, the linear component of the current response to an applied AC potential contains phase angle and/or admittance information that may be correlated to the concentration of the medically significant component. Also typically, the fundamental linear component of the current response is utilized in the disclosed systems and methods. Harmonics of the fundamental linear component may also be used. Other methods and devices are disclosed.

Les systèmes et procédés de la présente invention utilisent une composante linéaire d'une réponse en courant faradique non linéaire générée par un échantillon de fluide biologique lorsqu'un potentiel d'excitation en courant alternatif suffisant pour produire une telle réponse en courant faradique est appliqué à l'échantillon, afin de calculer la concentration d'un composant médicalement significatif dans l'échantillon de fluide biologique. La réponse en courant est créée par l'excitation de processus électrochimiques à l'intérieur de l'échantillon par le potentiel appliqué. Typiquement, la composante linéaire de la réponse en courant à un potentiel en courant alternatif appliqué contient des informations d'angle de phase et/ou d'admittance qui peuvent être corrélées à la concentration du composant médicalement significatif. Egalement typiquement, la composante linéaire fondamentale de la réponse en courant est utilisée dans les systèmes et procédés divulgués. Des harmoniques de la composante linéaire fondamentale peuvent également être utilisées. L'invention concerne également d'autres procédés et dispositifs.

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