System and method for controlling a mammalian cell culture...

C - Chemistry – Metallurgy – 12 – M

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C12M 3/00 (2006.01) C12M 1/06 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2733152

A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow;.

L'invention concerne un système et un procédé pour commander un procédé de culture cellulaire de mammifère. Une telle commande du processus de culture cellulaire implique une commande du niveau du dioxyde de carbone dissous dans le milieu de culture cellulaire, et l'aptitude résultante à empêcher des augmentations du niveau d'osmolalité est obtenue par un lavage amélioré de dioxyde de carbone avec peu ou pas de détérioration des cellules de mammifère. Les procédés et systèmes décrits de lavage de dioxyde de carbone comprennent des mécanismes d'échange de gaz de surface améliorés dans la cuve de bioréacteur, par l'utilisation d'une hélice à écoulement vers le haut combinée avec des déflecteurs verticaux pour transformer des mouvements tourbillonnants du liquide en un écoulement largement vertical.

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