C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/58 (2006.01) A61P 31/04 (2006.01) C07D 307/02 (2006.01)
Patent
CA 2743591
A method for inhibiting the growth of a microorganism using an effective amount of one or more of the following synthetic brominated furanones: (i) 4-bromo-5Z- (bromomethylene)-3--methylfuran-2-one; (ii) 3-(dibromomethyl)-5-(dibromomethylene)furan-2-one; (iii) 3-(bromomethyl)-5-(dibro-momethylene)furan-2-one; (iv) 4--bromo-3- (bromomethyl)-5Z-(bro-momethylene)furan-2-one; or (v) 4-bromo-5-(dibromomethyl)-3--methylfuran-2(5H)-one. The brominated furanones inhibit the growth of both fungi and bacteria, including the fugnal species Candida albicans, Gloeophyllum trabeum, Chaetomium globosum, and Trametes versicolor and the bacterial species Pseu-domonas aeruginosa. The brominated fu-ranones can be used topically or internally to treat human infections, and can be used to treat other objects, such as wood build-ing supplies, to prevent fungal rot.
La présente invention concerne un procédé d'inhibition de la multiplication d'un microorganisme à l'aide d'une quantité efficace de l'une ou plusieurs des furanones bromées synthétiques suivantes : (i) 4-bromo-5Z-(bromométhylène)-3-méthylfuran-2-one ; (ii) 3-(dibromométhyl)-5-(dibromométhylène)furan-2-one ; (iii) 3-(bromométhyl)-5-(dibromométhylène)furan-2-one ; (iv) 4-bromo-3-(bromométhyl)-5Z-(bromométhylène)furan-2-one ; et (v) 4-bromo-5-(dibromométhyl)-3-méthylfuran-2(5H)-one. Ces furanones bromées inhibent la croissance de champignons et de bactéries, notamment des espèces fongiques Candida albicans, Gloeophyllum trabeum, Chaetomium globosum et Trametes versicolor, et de l'espèce bactérienne Pseudomonas aeruginosa. Elles peuvent être utilisées par voie topique ou interne pour traiter des infections humaines, mais aussi d'autres objets tels que des matériaux de construction en bois, afin d'empêcher la pourriture fongique.
Luk Yan-Yeung
Ren Dacheng
Riches Mckenzie & Herbert Llp
Syracuse University
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