G - Physics – 06 – F
Patent
G - Physics
06
F
G06F 17/00 (2006.01) A61B 5/0452 (2006.01) A61B 5/0468 (2006.01) A61B 5/0456 (2006.01)
Patent
CA 2357599
A system and method for statistically analyzing QT interval as a function of changes in the RR interval. The system and method utilize three statistical comparisons to fully characterize the QT response: (1) the comparison of curves to give an overall effect; (2) the incidence of points exceeding a baseline upper 95% single-point prediction bound to reflect the degree of heterogeneity of ventricular repolarization; and (3) the magnitude of these points to provide a quantitative assessment of treatment-induced changes in the QT-RR relationship. The system and method use the relationship between the QT interval and heart rate (RR interval) to reference a control baseline response. Data from mammals such as humans and dogs, and pharmacological maneuvers using both cardiac and non- cardiac therapeutic agents, may be used with this multi-parameter statistical system and method. Additionally, the system and method quantifies the incidence and magnitude of points lying outside the upper 95% single-point prediction limit of the regression analysis for vehicle versus treatment.
Depasquale Michael Joseph
Fossa Anthony Andrea
Raunig David Lee
Pfizer Products Inc.
Smart & Biggar
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