A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/08 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07H 19/06 (2006.01) C07J 75/00 (2006.01) C07K 1/13 (2006.01) C07K 1/16 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2450231
The invention relates to a new method for producing radio-halogenated compounds having very high specific radioactivity. The method improves the stability of the radio-labeled compound such that its biological and/or chemical activity is retained. The main aspect of the invention is that vitamin C and/or ethanol is added to the radiolabeled compound at either or both of just following attachment of the radio-halogen and during purification of the radio-halogenated compound from the labeling mixture, or during packaging for storage.
L'invention concerne un nouveau procédé de production de composés radio-halogénés présentant une radioactivité spécifique très élevée. Le procédé permet d'améliorer la stabilité du composé à marquage radioactif de façon à conserver son activité biologique et/ou chimique. L'invention se caractérise notamment en ce que l'on ajoute la vitamine C et/ou l'éthanol au composé à marquage radioactif soit à la fixation et/ou immédiatement après la fixation du radiohalogène et pendant la purification du composé radio-halogéné du mélange d'étiquetage, ou pendant l'emballage en vue du stockage.
Jml Biopharm Inc.
Sim & Mcburney
Simon Fraser University The University Of Alberta The University Of British Columbia Car
The University Of Toronto
The University Of Victoria Collectively Doing Business As Triumf
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