A - Human Necessities – 61 – N
Patent
A - Human Necessities
61
N
A61N 1/30 (2006.01)
Patent
CA 2546282
A system and method for transdermally delivering a biologically active agent comprising one or more electrodes having stratum corneum-piercing projections and a circuit that delivers an electrical signal to the electrodes to electroporate a cell membrane. Preferably, the system is configured to generate homogeneous electrical fields and, more preferably, to generate spherically or semispherically symmetrical electric fields. Methods of the invention include applying a first electric signal to facilitate transdermal transport of the agent and applying a second electric signal to facilitate intracellular transport of the agent.
L'invention porte sur un système et une méthode d'administration transdermique d'un agent biologiquement actif comportant une ou des électrodes munies de pointes pouvant traverser la couche cornée et un circuit électrique fournissant aux électrodes un signal électrique électroporant. Le système est de préférence conçu pour créer des champs électriques homogènes ou mieux, des champs électriques sphériques ou hémisphériques. Ladite méthode consiste à appliquer un premier signal électrique pour favoriser le transport transdermique de l'agent, puis à appliquer un deuxième signal électrique pour favoriser le transport intracellulaire de l'agent.
Phipps Joseph B.
Subramony Janasdhanan
Widera Georg
Alza Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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