System and method for transdermal vaccine delivery

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61B 17/20 (2006.01) A61J 1/00 (2006.01)

Patent

CA 2543639

A system and method for trandermally delivering a vaccine to a patient including an iontophoresis delivery device having a donor electrode, a Counter electrode, and electric circuitry for supplying iontophoresis energy to the electrodes, and a non-electroactive microprojection member having a plurality of stratum corneum-piercing microprojections extending therefrom. The vaccine can be contained in a hydrogel formulation in an agent reservoir disposed proximate the donor electrode, in a biocompatible coating that is disposed on the microprojections or in both.

L'invention concerne un système et une méthode permettant d'administrer de manière transdermique un vaccin à un patient, ledit système comprenant un dispositif d'administration par iontophorèse qui présente une électrode donatrice, une contre-électrode et un circuit électrique conçu pour acheminer de l'énergie de l'iontophorèse jusqu'aux électrodes, et un élément électro-actif à microprotubérances qui possède une pluralité de microprotubérances perçant la couche cornée et partant dudit élément. Ce vaccin peut être contenu dans une préparation d'hydrogel dans un réservoir d'agents disposé à proximité de l'électrode donatrice, dans un revêtement biocompatible placé sur les microprotubérances ou à la fois dans la préparation et dans ledit revêtement.

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