System and method of determining proteomic differences

Details System and method of determining proteomic differences System and method of determining proteomic differences

G - Physics

01

N

G01N 33/00 (2006.01) G01N 1/00 (2006.01) G01N 24/00 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) G01N 30/02 (2006.01) G01N 30/72 (2006.01)

Patent

CA 2453725

The present invention relates to a system and methods for identifying differential peptide expression in one or more peptide populations. Each population 109 is labeled with a discernable label and provides a mechanism to resolve mixed peptide populations 130 using mass spectroscopy-based techniques. Spectra 146 produced by the peptide sample are used to interrogate a spectral database in which peptide sequences of known spectra are stored. In addition to providing sequence information, the methods presented herein may be used to determine qualitative and quantitative measurements of peptide expression. These measurements may further be used to determine proteomic differences and novel peptide expression.

L'invention concerne un système et des procédés servant à identifier une expression peptidique différentielle dans une ou plusieurs populations de peptides. On marque chaque population (109) au moyen d'un marqueur pouvant être distingué et constituant un mécanisme permettant de résoudre le mélange de populations de peptides (130) au moyen de techniques basées sur la spectroscopie de masse. On utilise les spectres (146) produits par le spécimen de peptide pour interroger une base de données spectrale dans laquelle sont mémorisées des séquences de peptide possédant des spectres connus. En plus des informations fournies par ces procédés concernant les séquences, on peut les utiliser afin de déterminer des mesures qualitatives et quantitatives de l'expression peptidique. On peut également utiliser ces mesures afin de déterminer des différences protéomiques et une nouvelle expression peptidique.

Affiliated with

Also associated with

Rating

System and method of determining proteomic differences does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with System and method of determining proteomic differences, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method of determining proteomic differences will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1398923