C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 1/34 (2006.01)
Patent
CA 2495021
A system and methods for calculating at least one unknown metabolic flux of a plurality of cells. In one embodiment, the method includes the steps of constructing a metabolic network having a plurality of reaction components, the reaction components representing at least glycolysis, reduction of pyruvate to lactate, TCA cycle, and oxidative phosphorylation, measuring at least two metabolic rates of a plurality of cells corresponding to at least two of the metabolic network reactions, and calculating metabolic fluxes of a plurality of cells for the rest of the metabolic network reactions from at least two measured metabolic rates of a plurality of cells corresponding to at least two of the reactions.
L'invention concerne un système et des procédés permettant de calculer au moins un flux métabolique de plusieurs cellules. Dans un mode de réalisation, le procédé consiste à construire un réseau métabolique ayant plusieurs composants réactifs représentant au moins la glycolyse, la réduction de pyruvate en lactate, le cycle TCA, la phosphorylation oxydante, à mesurer au moins deux taux métaboliques de plusieurs cellules correspondant à au moins deux réactions du réseau métabolique, et à calculer les flux métaboliques de plusieurs cellules pour le restant des réactions du réseau métabolique à partir d'au moins deux taux métaboliques mesurés de plusieurs cellules correspondant à au moins deux réactions.
Balcarcel Robert
Baudenbacher Franz J.
Clark Lindsey
Mcguinness Owen
Prokop Ales
Gowling Lafleur Henderson Llp
Vanderbilt University
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