System and methods for rapid and automated screening of cells

Details System and methods for rapid and automated screening of cells System and methods for rapid and automated screening of cells

G - Physics

01

N

G01N 15/14 (2006.01) G01N 21/64 (2006.01) G01N 33/50 (2006.01) G02B 21/24 (2006.01)

Patent

CA 2485602

A system for performing automated cell screening in drug discovery includes an automated microscope (100), a fast autofocus device, and a digital imaging system (500). Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

La présente invention concerne un système permettant d'exécuter un criblage automatique de cellules pour la recherche de médicament, ce système incluant un microscope automatisé (100), un dispositif rapide de mise au point automatique, et un système d'imagerie numérique (500). Des logiciels permettent la mise en oeuvre de traitements servant à segmenter et quantifier le matériau cellulaire pertinent avec un minimum d'interventions de l'utilisateur. L'invention apporte ainsi des améliorations touchant divers domaines. Ainsi, le recours à des procédés connus de traitement d'image permet une segmentation automatique. Des jeux de mesures connues, des décomptes de pixels notamment, fournissent des références fiables dans plusieurs domaines de la biologie. On utilise des composants permettant l'automatisation du positionnement, de la mise au point optique, de l'imagerie et du traitement d'une multiplicité d'échantillons, ces composants étant intégrés sous forme de systèmes dans lesquels on peut mettre en oeuvre les procédés de segmentation et de mesure. Enfin, les composants ainsi que les procédés ont été adaptés pour former des systèmes permettant un criblage des cellules qui soit hautement automatisé et plus rapide.

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