G - Physics – 01 – N
Patent
G - Physics
01
N
324/23
G01N 27/327 (2006.01) G01N 27/414 (2006.01)
Patent
CA 1318353
A SYSTEM EMPLOYING A BIOSENSOR TO MONITOR A CHARACTERISTIC OF A SELECT COMPONENT IN A MEDIUM Abstract of the Disclosure A measuring instrument is disclosed having a reversibly selective binding protein immobilized upon the insulated-gate region of a field-effect transistor located on a sensor With the sensor immersed in solution, the proteinbinds a select component of the solution to the gate producing an effect on a current flowing through the IGFET. A plurality of such binding protein-IGFET arrangements can be provided on the same sensor, including the same binding proteins having different binding coefficients KD or an array of proteins with different ligand specificity and/or affinity. Analysis of the IGFET's response to binding by a microprocessor allows, for example, the concentration of the component in solution to be determined. With a plurality of different binding proteins employed, the concentration of different components can be determined. Similarly, with binding proteins employed having different binding coefficients KD, the output of the sensor can be analyzed in either a digital oranalog manner, or some combination of the two. To release the component from the protein, heat can be applied to the sensor through a resistive bank integrated into the sensor chip. Alternatively, the application of a reverse bias to the gate can be used to enhance release.
565850
Cheung Peter Wing-Poon
Furlong Clement Eugene Jr.
Weiler Edward Bakewell
Smart & Biggar
Washington Technology Center (the)
LandOfFree
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