A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/70 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2693912
The invention relates to a system for controlled release of an active principle, comprising at least (a) a degradable polymer matrix which produces acid compounds and (b) at least one acid-sensitive complex of an active principle having at least one electrostatic charge and a complexing polyelectrolyte partner of opposite charge which complexes with the active principle. The invention further relates to a method for preparation of such a system. The release of the active principle (7P) is prolonged over 18 days (ternary system PMLA/7P/PLAGA) in comparison to binary systems (7P/PLAGA) and (PMLA/7P).
La présente invention concerne un système à libération contrôlée d'un principe actif comportant au moins (a) une matrice polymère dégradable génératrice de composés acides et (b) au moins un complexe acidosensible entre un principe actif doté d'au moins une charge électrostatique et un partenaire polyélectrolyte complexant le principe actif, de charge opposée. Elle concerne également un procédé de préparation d'un tel système. La libération du principe actif (7P) est prolongée sur 18 jours (système ternaire PMLA/7P/PLAGA) par rapport aux systèmes binaires (7P/PLAGA) et (PMLA/7P).
Boustta Mahfoud
Leclercq Laurent
Vert Michel
Centre National de La Recherche Scientifique
Goudreau Gage Dubuc
Universite de Montpellier I.
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