System for delivering an active substance for sustained release

Details System for delivering an active substance for sustained release System for delivering an active substance for sustained release

A - Human Necessities

61

K

A61K 9/58 (2006.01) A61K 9/50 (2006.01) A61K 9/64 (2006.01)

Patent

CA 2122592

A system for delivering an active substance has sustained release of the active substance in the intestinal tract. This delivery system is especially useful for an active substance such as a .beta.-lactam antibiotic which preferably has minimal exposure to the ac- idic environment of the stomach. Particles comprise an active ingredient disposed in a core which has at least one coating of a prolamine and one coating of an enteric compound thereon. The particles may be very small and suspended in a liquid medium.

Un système pour introduire une substance active qui est relarguée dans l'intestin. Ce système est particulièrement utile pour une substance active comme les bêta-lactamines, qui doivent, de préférence, être exposées le moins possible à l'environnement acide de l'estomac. Les particules se composent d'un ingrédient actif déposé dans un noyau revêtu d'au moins une couche de prolamine et d'une couche d'un composé gastro-résistant. Les particules peuvent être très petites et être en suspension dans un milieu liquide.

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