System for detecting protease

Details System for detecting protease System for detecting protease

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 19/00 (2006.01) C12Q 1/04 (2006.01) C12Q 1/37 (2006.01) G01N 21/64 (2006.01) G01N 35/00 (2006.01)

Patent

CA 2457059

Disclosed is a system for detecting a protease inside a cell. ln one embodiment, the system includes a chimeric protein that comprises as covalently linked components: 1) at least one optionally masked signal protein; 2) at least one protease-specific cleavage site; and 3) at least one detectable amino acid sequence. The invention bas a wide spectrum of applications including use in the detection of novel protease inhibitors inside cells and tissue.

L'invention concerne un système permettant de détecter une protéase dans une cellule. Dans un mode de réalisation, ledit système comprend une protéine chimère qui renferme des composants liés par covalence, à savoir: 1) au moins une protéine signal éventuellement masquée; 2) au moins un site de clivage spécifique d'unE protéase; et 3) et au moins une séquence aminoacide détectable. L'invention possède un grand éventail d'applications notamment l'utilisation de la détection de nouveaux inhibiteurs de protéase dans les cellules et les tissus.

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