System for enhancing cardiac signal sensing by cardiac...

A - Human Necessities – 61 – M

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A61M 5/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61M 37/00 (2006.01) A61N 1/05 (2006.01) A61N 1/362 (2006.01) A61B 17/34 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2261022

The present invention provides delivery systems for delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave. More specifically, there is provided a system for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.

L'invention concerne des systèmes d'apport de matériau génétique à base de protéines de canal ionique dans des cellules cardiaques situées dans des zones adjacentes aux zones où une électrode doit être positionnée dans le coeur d'un patient, de sorte que le rapport signal-bruit des signaux cardiaques, telle que l'onde primaire, soit amélioré ou corrigé. Plus spécifiquement, l'invention se rapporte à un système pour apporter des protéines de canal ionique ou des molécules d'acide nucléique codant lesdites protéines, dans un site du coeur adjacent à une électrode de sorte que son expression soit augmentée et qu'ainsi, l'amplitude du signal cardiaque soit augmentée et que la détection des signaux cardiaques produits par le stimulateur cardiaque implanté soit améliorée.

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