System for exsanguinous metabolic support of an organ or tissue

Details System for exsanguinous metabolic support of an organ or tissue System for exsanguinous metabolic support of an organ or tissue

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61K 31/70 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2376607

An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed. The system employs a warm perfusion solution capable of supporting the metabolism of the organ or tissue thereby preserving its functional integrity. The system also monitors parameters of the circulating perfusion solution, such as pH, temperature, osmolarity, flow rate, vascular pressure and partial pressure of respiratory gases, and regulates them to insure that the organ is maintained under near-physiologic conditions. Use of the system for long-term maintenance of organs for transplantation, for resuscitation and repair of organs having sustained warm ischemic damage, as a pharmaceutical delivery system and prognosticator of posttransplantation organ function is also disclosed.

L'invention concerne un système support métabolique exsanguiné permettant de maintenir presque normal le rythme métabolique d'un organe ou tissu. Le système utilise une solution de perfusion chaude capable de supporter le métabolisme d'un organe ou tissu, ce qui lui conserve son intégrité fonctionnelle. Le système surveille également les paramètres de la solution de perfusion circulante, par exemple pH, température, osmolarité, débit, pression vasculaire et pression partielle de gaz respiratoires, et les régule afin que l'organe se maintienne dans des conditions presque physiologiques. L'invention traite également de l'utilisation du système aux fins d'une conservation de longue durée d'organes pour greffe, réanimation et reconstitution d'organes ayant subi des lésions ischémiques chaudes, comme système d'administration pharmaceutique et pronostiqueur de fonction de post-greffe d'organe.

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