System for external control of oncolytic virus replication

Details System for external control of oncolytic virus replication System for external control of oncolytic virus replication

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/34 (2006.01) C12N 15/67 (2006.01)

Patent

CA 2516652

Compositions, methods and a system for external regulation of oncolytic virus replication are provided. The oncolytic virus contains a cell type-specific transcriptional regulatory element (CT-TRE) and an inducible transactivator regulated transcriptional regulatory element. The virus preferentially replicates in cells that allow a CT-TRE to function. In addition, the concentration of an inducing agent or condition is used to regulate a transactivator regulated transcriptional regulatory element, thereby providing at least two levels of control of oncolytic viral replication.

L'invention concerne des compositions, des procédés et un système permettant la régulation externe de la reproduction d'un virus oncolytique. Le virus oncolytique contient un élément régulateur transcriptionnel spécifique à un type cellulaire (CT-TRE) ainsi qu'un élément régulateur transcriptionnel régulé par un gène transactivateur inducible. Le virus se reproduit de préférence dans des cellules qui permettent à CT-TRE de fonctionner. En outre, la concentration d'un agent ou d'une condition d'induction est utilisée pour réguler un élément régulateur transcriptionnel régulé par un gène transactivateur, ce qui permet d'obtenir au moins deux niveaux de commande de la reproduction virale oncolytique.

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